Dr. Niles Caulder (Timothy Dalton) is a scientist who can save people from severe accidents. Four children live in his house. Cliff Steele (Brendan Fraser) is a robot man who only retains his brain from his previous body. Rita Farr (April Bowlby) uncontrollably changing her shape. Larry Trainor (Matt Bomer), who is wrapped in bandages like a mummy due to burns all over his body, and Crazy Jane (Diane Guerrero), a girl with 64 personalities. When one day Dr. Caulder disappears without a trace, his patients decide to join forces to find him.